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Article

Polymorphisms within insulin-degrading enzyme (IDE) gene determine insulin metabolism and risk of type 2 diabetes.

Journal of molecular medicine (Berlin, Germany) - 1 Nov 2009

Rudovich Natalia, Pivovarova Olga, Fisher Eva, Fischer-Rosinsky Antje, Spranger Joachim, Möhlig Matthias, Schulze Matthias B, Boeing Heiner, Pfeiffer Andreas F H

Abstract excerpt

Insulin-degrading enzyme (IDE) is the ubiquitously expressed major enzyme responsible for insulin degradation. Insulin-degrading enzyme gene is located on chromosome region 10q23-q25 and exhibits a well-replicated peak of linkage with type 2 diabetes (T2DM). Several genetic association studies examined IDE gene as a susceptibility gene for T2DM with controversial results. However, pathophysiological mechanisms...

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Identifiers

PMID: 19809796
DOI: 10.1007/s00109-009-0540-6

Genes

IDE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Polymorphisms within insulin-degrading enzyme (IDE) gene determine insulin metabolism and risk of type 2 diabetes.PMID 19809796Read ↗

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Loss of postprandial insulin clearance control by Insulin-degrading enzyme drives dysmetabolism traits.Semantic proximity Read ↗

High-density haplotype structure and association testing of the insulin-degrading enzyme (IDE) gene with type 2 diabetes in 4,206 people.Semantic proximity Read ↗

Variants in the insulin-degrading enzyme gene are associated with metabolic syndrome in Chinese elders.Semantic proximity Read ↗

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