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Article

Disorder-specific effects of polymorphisms at opposing ends of the Insulin Degrading Enzyme gene.

BMC medical genetics - 22 Nov 2011

Bartl Jasmin, Scholz Claus-Jürgen, Hinterberger Margareta, Jungwirth Susanne, Wichart Ildiko, Rainer Michael K, Kneitz Susanne, Danielczyk Walter, Tragl Karl H, Fischer Peter, Riederer Peter, Grünblatt Edna

Abstract excerpt

BACKGROUND: Insulin-degrading enzyme (IDE) is the ubiquitously expressed enzyme responsible for insulin and amyloid beta (Aβ) degradation. IDE gene is located on chromosome region 10q23-q25 and exhibits a well-replicated peak of linkage with Type 2 diabetes mellitus (T2DM). Several genetic association studies examined IDE gene as a susceptibility gene for Alzheimer's disease (AD), however with controversial...

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Identifiers

PMID: 22107728
DOI: 10.1186/1471-2350-12-151
PMCID: PMC3266204

Genes

IDE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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