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Article

Association of common genetic variation in the insulin/IGF1 signaling pathway with human longevity.

Aging cell - 1 Aug 2009

Pawlikowska Ludmila, Hu Donglei, Huntsman Scott, Sung Andrew, Chu Catherine, Chen Justin, Joyner Alexander H, Schork Nicholas J, Hsueh Wen-Chi, Reiner Alexander P, Psaty Bruce M, Atzmon Gil, Barzilai Nir, Cummings Steven R, Browner Warren S, Kwok Pui-Yan, Ziv Elad

Abstract excerpt

The insulin/IGF1 signaling pathways affect lifespan in several model organisms, including worms, flies and mice. To investigate whether common genetic variation in this pathway influences lifespan in humans, we genotyped 291 common variants in 30 genes encoding proteins in the insulin/IGF1 signaling pathway in a cohort of elderly Caucasian women selected from the Study of Osteoporotic Fractures (SOF). The cohort...

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Identifiers

PMID: 19489743
DOI: 10.1111/j.1474-9726.2009.00493.x
PMCID: PMC3652804

Genes

IGF1
AKT1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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