Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic variation in insulin/IGF-1 signaling pathways and longevity.

Ageing research reviews - 1 Apr 2011

Ziv Elad, Hu Donglei

Abstract excerpt

The insulin/IGF-1 pathway has been shown to affect lifespan and rate of aging in a variety of animals including worms, flies and mice. Genetic variation in this pathway may also affect human longevity. We review the evidence for the effect of this pathway on longevity with a focus on the genetic studies in humans to date. One gene, FOXO3A, a transcriptional factor homologous to daf-16, has been repeatedly...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aging
Share to Forkhead Box Protein O3
Share to Forkhead Transcription Factors

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Insulin

Share to Insulin-Like Growth Factor I

Share to Longevity

Share to Signal Transduction

Share to Transcription Factors

Source

Identifiers

PMID: 20868776
DOI: 10.1016/j.arr.2010.09.002

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic variation in insulin/IGF-1 signaling pathways and longevity.PMID 20868776Read ↗

FOXO3A genotype is strongly associated with human longevity.Semantic proximity Read ↗

Association of common genetic variation in the insulin/IGF1 signaling pathway with human longevity.Semantic proximity Read ↗

The role of genetic variants in human longevity.Semantic proximity Read ↗

Discovery of functional gene variants associated with human longevity: opportunities and challenges.Semantic proximity Read ↗

Association analyses of insulin signaling pathway gene polymorphisms with healthy aging and longevity in Americans of Japanese ancestry.Semantic proximity Read ↗

Caenorhabditis elegans DAF-16/FOXO transcription factor and its mammalian homologs associate with age-related diseaseSemantic proximity Read ↗

Association study of polymorphisms in FOXO3, AKT1 and IGF-2R genes with human longevity in a Han Chinese population.Semantic proximity Read ↗

Association between genetic variations in the insulin/insulin-like growth factor (Igf-1) signaling pathway and longevity: a systematic review and meta-analysis.Semantic proximity Read ↗

Insulin and agingSemantic proximity Read ↗

Genetics of human longevity: From variants to genes to pathwaysSemantic proximity Read ↗

Human insulin/IGF-1 and familial longevity at middle ageSemantic proximity Read ↗

Genetic polymorphism in long-lived people: Cues for the presence of an insulin/IGF-pathway-dependent network affecting human longevitySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.