Article
Loss of postprandial insulin clearance control by Insulin-degrading enzyme drives dysmetabolism traits.
Metabolism: clinical and experimental - 1 May 2021
Borges Diego O, Patarrão Rita S, Ribeiro Rogério T, de Oliveira Rita Machado, Duarte Nádia, Belew Getachew Debas, Martins Madalena, Andrade Rita, Costa João, Correia Isabel, Boavida José Manuel, Duarte Rui, Gardete-Correia Luís, Medina José Luís, Raposo João F, Jones John G, Penha-Gonçalves Carlos, Macedo M Paula
Abstract excerpt
Systemic insulin availability is determined by a balance between beta-cell secretion capacity and insulin clearance (IC). Insulin-degrading enzyme (IDE) is involved in the intracellular mechanisms underlying IC. The liver is a major player in IC control yet the role of hepatic IDE in glucose and lipid homeostasis remains unexplored. We hypothesized that IDE governs postprandial IC and hepatic IDE dysfunction...
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