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High-density haplotype structure and association testing of the insulin-degrading enzyme (IDE) gene with type 2 diabetes in 4,206 people.

Diabetes - 1 Jan 2006

Florez Jose C, Wiltshire Steven, Agapakis Christina M, Burtt Noël P, de Bakker Paul I W, Almgren Peter, Bengtsson Boström Kristina, Tuomi Tiinamaija, Gaudet Daniel, Daly Mark J, Hirschhorn Joel N, McCarthy Mark I, Altshuler David, Groop Leif

Abstract excerpt

The insulin-degrading enzyme is responsible for the intracellular proteolysis of insulin. Its gene IDE is located on chromosome 10, in an area with suggestive linkage to type 2 diabetes and related phenotypes. Due to the impact of genetic variants of this gene in rodents and the function of its protein product, it has been proposed as a candidate gene for type 2 diabetes. Various groups have explored the role of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 16380485

Genes

IDE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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High-density haplotype structure and association testing of the insulin-degrading enzyme (IDE) gene with type 2 diabetes in 4,206 people.PMID 16380485Read ↗

Association and haplotype analysis of the insulin-degrading enzyme (IDE) gene, a strong positional and biological candidate for type 2 diabetes susceptibility.Semantic proximity Read ↗

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Polymorphisms within insulin-degrading enzyme (IDE) gene determine insulin metabolism and risk of type 2 diabetes.Semantic proximity Read ↗

A genome-wide association study identifies novel risk loci for type 2 diabetes.Semantic proximity Read ↗

Concordant Association of Insulin Degrading Enzyme Gene (IDE) Variants with IDE mRNA, Aß, and Alzheimer's DiseaseSemantic proximity Read ↗

Variants in the insulin-degrading enzyme gene are associated with metabolic syndrome in Chinese elders.Semantic proximity Read ↗

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