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Global, cell non-autonomous gene regulation drives individual lifespan among isogenic C. elegans

1 Feb 2021

Abstract excerpt

reared in homogeneous environments are as variable in lifespan as outbred human populations. We hypothesized that persistent inter-individual differences in expression of key regulatory genes drives this lifespan variability. As a test, we examined the relationship between future lifespan and the expression of 22 microRNA promoter::GFP constructs. Surprisingly, expression of nearly half of these reporters, well...

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PMID: 33522488
DOI: 10.7554/elife.65026

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