Article
Proper Gcn5 histone acetyltransferase expression is required for normal anteroposterior patterning of the mouse skeleton.
Development, growth & differentiation - 1 Jun 2008
Lin Wenchu, Zhang Zhijing, Chen Chih-Hsin, Behringer Richard R, Dent Sharon Y R
Abstract excerpt
Histone acetylation plays important roles in gene regulation. However, the functions of individual histone acetyltransferases (HATs) in specific developmental transcription programs are not well defined. To define the functions of Gcn5, a prototypical HAT, during mouse development, we have created a series of mutant Gcn5 alleles. Our previous work revealed that deletion of Gcn5 leads to embryonic death soon after...
Topics
- Animals
- Body Patterning
- Bone and Bones
- Chromatin
- Gene Expression Regulation, Developmental
- Gene Expression Regulation, Enzymologic
- Histone Acetyltransferases
- Histones
- Homeodomain Proteins
- Mice
- Mutation
- p300-CBP Transcription Factors