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Article

Proper expression of the Gcn5 histone acetyltransferase is required for neural tube closure in mouse embryos.

Developmental dynamics : an official publication of the American Association of Anatomists - 1 Apr 2008

Lin Wenchu, Zhang Zhijing, Srajer Geraldine, Chen Yi Chun, Huang Maosheng, Phan Huy M, Dent Sharon Y R

Abstract excerpt

Histone acetyltransferases (HATs) are important to gene activation, altering chromatin structures to facilitate association of transcription proteins with gene promoters. The functions of individual HATs in mammalian developmental are not well defined. Our previous studies demonstrated that Gcn5, a prototypical HAT, is required for mesodermal maintenance in early embryos. Homozygous Gcn5 null embryos die soon...

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PMID: 18330926
DOI: 10.1002/dvdy.21479
PMCID: PMC3082922

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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