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Article

Loss of Hoxa5 function affects Hox gene expression in different biological contexts.

Scientific reports - 28 Dec 2024

Frenette Béatrice, Guéno Josselin, Houde Nicolas, Landry-Truchon Kim, Giguère Anthony, Ashok Theyjasvi, Ryckman Abigail, Morton Brian R, Mansfield Jennifer H, Jeannotte Lucie

Abstract excerpt

Hoxa5 plays numerous roles in development, but its downstream molecular effects are mostly unknown. We applied bulk RNA-seq assays to characterize the transcriptional impact of the loss of Hoxa5 gene function in seven different biological contexts, including developing respiratory and musculoskeletal tissues that present phenotypes in Hoxa5 mouse mutants. This global analysis revealed few common transcriptional...

Topics

Animals
Homeodomain Proteins
Mice
Genes, Homeobox
Gene Expression Regulation, Developmental
Phenotype
Lung
Mutation
Transcription Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39730789
DOI: 10.1038/s41598-024-81867-0
PMCID: PMC11680909

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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