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Article

The loss of<i>Hoxa5</i>function promotes Notch-dependent goblet cell metaplasia in lung airways

29 May 2012

Abstract excerpt

Hox genes encode transcription factors controlling complex developmental processes in various organs. Little is known, however, about how HOX proteins control cell fate. Herein, we demonstrate that the goblet cell metaplasia observed in lung airways from Hoxa5(-/-) mice originates from the transdifferentiation of Clara cells. Reduced CC10 expression in Hoxa5(-/-) embryos indicates that altered cell specification...

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PMID: 23213461
DOI: 10.1242/bio.20121701

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