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Article

Loss of Hdac4 in osteoprogenitors impairs postnatal trabecular and cortical bone formation, resulting in a dwarfism and osteopenia phenotype in mice.

The Journal of biological chemistry - 1 Dec 2024

Wang YunFei, Zhou Raorao, Dong Zhengquan, Wang Wenting, Guo Li, Sun Jian, Rong Xueqin, Li Pengcui

Abstract excerpt

HDAC4 is a class II histone deacetylation protein with a well-characterized role in chondrocyte differentiation and skeletal development, and dysregulated expression or haploinsufficiency of Hdac4 leads to skeletal formation and malformation disorders. The early lethality of Hdac4 ablation mice hindered further investigation of its role in postnatal bone growth and development. Therefore, this study aims to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39481602
DOI: 10.1016/j.jbc.2024.107941
PMCID: PMC11664417

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