Explaining the preponderance of Kras mutations in human cancer: An isoform-specific function in stem cell expansion.

Abstract excerpt

Mutationally activated forms of the three closely related Ras isoforms, Kras, Hras and Nras can each exert oncogenic activity, and activated alleles arise in a variety of human cancers. However, mutant Kras is, by far, the most frequently observed Ras isoform in cancer, and is most frequently detected in tumors derived from endodermal tissues, including pancreas, lung and colon. We have recently reported findings...

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