Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

RAS signalling in the colorectum in health and disease.

Cell communication & adhesion - 1 Feb 2012

Poulogiannis George, Luo Feijun, Arends Mark J

Abstract excerpt

RAS proteins act as molecular switches between several homeostatic inputs and signal transduction pathways that regulate important cellular processes including cell growth, differentiation and survival. Activating mutations change the function of normal proto-oncogenic RAS proteins to oncogenic RAS proteins that trigger a wide range of downstream effectors altering expression of transcription factors that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to MicroRNAs
Share to Antibodies
Share to Colon

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Colorectal Neoplasms

Share to Protein Processing, Post-Translational

Share to ras Proteins

Share to Rectum

Share to Signal Transduction

Source

Identifiers

PMID: 22233291
DOI: 10.3109/15419061.2011.649380

Genes

KRAS
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

RAS signalling in the colorectum in health and disease.PMID 22233291Read ↗

Recent Updates on the Significance of KRAS Mutations in Colorectal Cancer Biology.Semantic proximity Read ↗

Clinical Relevance of KRAS in Human CancersSemantic proximity Read ↗

RAS signaling in carcinogenesis, cancer therapy and resistance mechanisms.Semantic proximity Read ↗

A Comparative Analysis of Individual RAS Mutations in Cancer BiologySemantic proximity Read ↗

Deciphering the role of KRAS gene in oncogenesis: Focus on signaling pathways, genetic alterations in 3'UTR, KRAS specific miRNAs and therapeutic interventions.Semantic proximity Read ↗

Similar but different: distinct roles for KRAS and BRAF oncogenes in colorectal cancer development and therapy resistance.Semantic proximity Read ↗

RAS: Striking at the Core of the Oncogenic CircuitrySemantic proximity Read ↗

Gene of the month: KRAS.Semantic proximity Read ↗

Differential gene expression signatures between colorectal cancers with and without KRAS mutations: Crosstalk between the KRAS pathway and other signalling pathwaysSemantic proximity Read ↗

The Abundance of KRAS and RAS Gene Mutations in Cancer.Semantic proximity Read ↗

Profiling the kinome in oncogenic RAS mutant cellsSemantic proximity Read ↗

KRAS Pathways: A Potential Gateway for Cancer Therapeutics and Diagnostics.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.