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Article

The mystery of oncogenic KRAS: Lessons from studying its wild-type counter part.

Small GTPases - 2 Oct 2017

Chang Yuan-I, Damnernsawad Alisa, Kong Guangyao, You Xiaona, Wang Demin, Zhang Jing

Abstract excerpt

Using conditional knock-in mouse models, we and others have shown that despite the very high sequence identity between Nras and Kras proteins, oncogenic Kras displays a much stronger leukemogenic activity than oncogenic Nras in vivo. In this manuscript, we will summarize our recent work of characterizing wild-type Kras function in adult hematopoiesis and in oncogenic Kras-induced leukemogenesis. We attribute the...

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Identifiers

PMID: 27449543
DOI: 10.1080/21541248.2016.1215656
PMCID: PMC5680677

Genes

KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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