Article
Ras protein abundance correlates with Ras isoform mutation patterns in cancer.
Oncogene - 1 Apr 2023
Hood Fiona E, Sahraoui Yasmina M, Jenkins Rosalind E, Prior Ian A
Abstract excerpt
Activating mutations of Ras genes are often observed in cancer. The protein products of the three Ras genes are almost identical. However, for reasons that remain unclear, KRAS is far more frequently mutated than the other Ras isoforms in cancer and RASopathies. We have quantified HRAS, NRAS, KRAS4A and KRAS4B protein abundance across a large panel of cell lines and healthy tissues. We observe consistent patterns...
Topics
- Humans
- ras Proteins
- Proto-Oncogene Proteins p21(ras)
- Mutation
- Signal Transduction
- Neoplasms
- Protein Isoforms