Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Clinical Relevance of KRAS in Human Cancers

1 Jan 2010

Abstract excerpt

The KRAS gene (Ki-ras2 Kirsten rat sarcoma viral oncogene homolog) is an oncogene that encodes a small GTPase transductor protein called KRAS. KRAS is involved in the regulation of cell division as a result of its ability to relay external signals to the cell nucleus. Activating mutations in the KRAS gene impair the ability of the KRAS protein to switch between active and inactive states, leading to cell...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Cell death mechanisms and regulation
Share to Protein Kinase Regulation and GTPase Signaling

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 20617134
DOI: 10.1155/2010/150960

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Clinical Relevance of KRAS in Human CancersPMID 20617134Read ↗

KRAS Pathways: A Potential Gateway for Cancer Therapeutics and Diagnostics.Semantic proximity Read ↗

KRAS Mutations in Cancer: From Molecular Insights to Therapeutic Strategies.Semantic proximity Read ↗

Targeting KRAS in Cancer: Promising Therapeutic StrategiesSemantic proximity Read ↗

Kirsten Ras* oncogene: significance of its discovery in human cancer research.Semantic proximity Read ↗

The current understanding on the impact of KRAS on colorectal cancer.Semantic proximity Read ↗

Role of oncogenic KRAS in the prognosis, diagnosis and treatment of colorectal cancer.Semantic proximity Read ↗

Deciphering the role of KRAS gene in oncogenesis: Focus on signaling pathways, genetic alterations in 3'UTR, KRAS specific miRNAs and therapeutic interventions.Semantic proximity Read ↗

KRAS: From undruggable to a druggable Cancer Target.Semantic proximity Read ↗

Molecular epidemiology and diagnostics of KRAS mutations in human cancer.Semantic proximity Read ↗

Recent Updates on the Significance of KRAS Mutations in Colorectal Cancer Biology.Semantic proximity Read ↗

Why isn't an oncogenic mutation in KRAS enough to induce and sustain transformation?Semantic proximity Read ↗

RAS signaling in carcinogenesis, cancer therapy and resistance mechanisms.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.