Article
Activated Kras, but not Hras or Nras, may initiate tumors of endodermal origin via stem cell expansion.
Molecular and cellular biology - 1 Apr 2008
Quinlan Margaret P, Quatela Steven E, Philips Mark R, Settleman Jeffrey
Abstract excerpt
The three closely related human Ras genes, Hras, Nras, and Kras, are all widely expressed, engage a common set of downstream effectors, and can each exhibit oncogenic activity. However, the vast majority of activating Ras mutations in human tumors involve Kras. Moreover, Kras mutations are most frequently seen in tumors of endodermally derived tissues (lung, pancreas, and colon), suggesting that activated Kras...
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