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An <i>in vivo</i> KRAS allelic series reveals distinct phenotypes of common oncogenic variants

2019-11-20

Abstract excerpt

<h4>ABSTRACT</h4> KRAS is the most frequently mutated oncogene in cancer. Tumor sequencing has revealed a complex spectrum of KRAS mutations across different cancer types, yet there is little understanding how specific KRAS alterations impact tumor in initiation, progression, or therapy response. Using high-fidelity CRISPR-based engineering, we created an allelic series of new LSL-Kras mutant mice, reflecting co...

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Literature Corpus work
ffdbc0d6-d660-5808-a983-e97acd5cb694
DOI
10.1101/847509
Open publication

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An <i>in vivo</i> KRAS allelic series reveals distinct phenotypes of common oncogenic variantsDOI 10.1101/847509
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