Article

Isoform-specific Ras expression and signalling

2016-01-01

Abstract excerpt

Ras proteins are GTPases that are molecular central hubs for propagation of intracellular signals that are involved in diverse processes, including cell differentiation and proliferation. The four main Ras isoforms, HRas, NRas and the two KRas splice variants, KRasA and KRasB, are highly homologous and conserved proto-oncogenes that constitute a paradigm of cellular transformation. While all RAS genes are commonly...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6ac46e55-22fb-58da-9052-44d93f4f316c
DOI: 10.17638/03000021

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Isoform-specific Ras expression and signallingDOI 10.17638/03000021Read

Functional Specificity of Ras Isoforms: So Similar but So DifferentSemantic proximity Read

Isoform-Specific Ras Functions in Development and CancerSemantic proximity Read

Decoding RAS isoform and codon-specific signalling.Semantic proximity Read

Ras Isoforms from Lab Benches to Lives-What Are We Missing and How Far Are We?Semantic proximity Read

The role of wild type RAS isoforms in cancer.Semantic proximity Read

RAS: Striking at the Core of the Oncogenic CircuitrySemantic proximity Read

Profiling the kinome in oncogenic RAS mutant cellsSemantic proximity Read

A Comparative Analysis of Individual RAS Mutations in Cancer BiologySemantic proximity Read

RAS signaling in carcinogenesis, cancer therapy and resistance mechanisms.Semantic proximity Read

Ras oncogenes and their downstream targets.Semantic proximity Read

Biology, pathology, and therapeutic targeting of RAS.Semantic proximity Read

Ras protein abundance correlates with Ras isoform mutation patterns in cancer.Semantic proximity Read