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Article

Oncogenic Kras Initiates Leukemia in Hematopoietic Stem Cells

12 Mar 2009

Abstract excerpt

How oncogenes modulate the self-renewal properties of cancer-initiating cells is incompletely understood. Activating KRAS and NRAS mutations are among the most common oncogenic lesions detected in human cancer, and occur in myeloproliferative disorders (MPDs) and leukemias. We investigated the effects of expressing oncogenic Kras(G12D) from its endogenous locus on the proliferation and tumor-initiating properties...

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PMID: 19296721
DOI: 10.1371/journal.pbio.1000059

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Oncogenic Kras Initiates Leukemia in Hematopoietic Stem CellsPMID 19296721Read ↗

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