Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A functional promoter variant in IL12B predisposes to cerebral malaria.

Human molecular genetics - 15 Jul 2008

Marquet Sandrine, Doumbo Ogobara, Cabantous Sandrine, Poudiougou Belco, Argiro Laurent, Safeukui Innocent, Konate Salimata, Sissoko Sibiri, Chevereau Estelle, Traore Abdoulaye, Keita Mamadou M, Chevillard Christophe, Abel Laurent, Dessein Alain J

Abstract excerpt

The role of the Th1 pathway in the pathogenesis of severe malaria is unclear. We recently reported that a polymorphism with increasing IFNG transcription is associated with protection against cerebral malaria (CM). Interleukin-12 is required for Th1 cell differentiation, which is characterized by the production of interferon-gamma. We investigated 21 markers in IL12-related genes, including IL12A and IL12B...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cohort Studies
Share to Heterozygote

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Interleukin-12 Subunit p40

Share to Malaria, Cerebral

Share to Odds Ratio

Share to Promoter Regions, Genetic

Share to Receptors, Interleukin-12

Share to STAT4 Transcription Factor

Source

Identifiers

PMID: 18413324
DOI: 10.1093/hmg/ddn118

Genes

IFNG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A functional promoter variant in IL12B predisposes to cerebral malaria.PMID 18413324Read ↗

A promoter polymorphism in the gene encoding interleukin-12 p40 (IL12B) is associated with mortality from cerebral malaria and with reduced nitric oxide productionSemantic proximity Read ↗

A replication study of the association between the IL12B promoter allele CTCTAA and susceptibility to cerebral malaria in Thai population.Semantic proximity Read ↗

Haplotypes of IL12B promoter polymorphisms condition susceptibility to severe malaria and functional changes in cytokine levels in Thai adults.Semantic proximity Read ↗

CXCL10 gene promoter polymorphism -1447A>G correlates with plasma CXCL10 levels and is associated with male susceptibility to cerebral malaria.Semantic proximity Read ↗

Cord Blood IL-12 Confers Protection to Clinical Malaria in Early Childhood Life.Semantic proximity Read ↗

Deficient IL-12p70 secretion by dendritic cells based on IL12B promoter genotype.Semantic proximity Read ↗

PRELIMINARY REPORT ON THE PUTATIVE ASSOCIATION OF IL10 -3575 T/A GENETIC POLYMORPHISM WITH MALARIA SYMPTOMS.Semantic proximity Read ↗

IFNGR1 gene promoter polymorphisms and susceptibility to cerebral malaria.Semantic proximity Read ↗

Functional promoter haplotypes of interleukin-18 condition susceptibility to severe malarial anemia and childhood mortality.Semantic proximity Read ↗

Interferon-alpha receptor-1 (IFNAR1) variants are associated with protection against cerebral malaria in the Gambia.Semantic proximity Read ↗

Type I Interferon Receptor Variants in Gene Regulatory Regions are Associated with Susceptibility to Cerebral Malaria in Malawi.Semantic proximity Read ↗

Combined promoter haplotypes of the IL10R genes are associated with protection against severe malaria in Gabonese children.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.