Article
Functional promoter haplotypes of interleukin-18 condition susceptibility to severe malarial anemia and childhood mortality.
Infection and immunity - 1 Dec 2011
Anyona Samuel B, Kempaiah Prakasha, Raballah Evans, Ouma Collins, Were Tom, Davenport Gregory C, Konah Stephen N, Vulule John M, Hittner James B, Gichuki Charity W, Ong'echa John M, Perkins Douglas J
Abstract excerpt
Severe malarial anemia (SMA) is a leading cause of morbidity and mortality in children residing in regions where Plasmodium falciparum transmission is holoendemic. Although largely unexplored in children with SMA, interleukin-18 (IL-18) is important for regulating innate and acquired immunity in inflammatory and infectious diseases. As such, we selected two functional single-nucleotide polymorphisms (SNPs) in the...
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