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Article

Deficient IL-12p70 secretion by dendritic cells based on IL12B promoter genotype.

Genes and immunity - 1 Aug 2004

Müller-Berghaus J, Kern K, Paschen A, Nguyen X D, Klüter H, Morahan G, Schadendorf D

Abstract excerpt

Interleukin-12 (IL-12), a heterodimeric cytokine, is important in the generation of a Th1-biased immune response. Several polymorphisms have been described in IL12B, the gene encoding the p40 subunit of IL-12. A bi-allelic polymorphism within the IL12B promoter region has been reported to show association with diseases as diverse as severe childhood asthma and fatal cerebral malaria. In order to define the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 15175646
DOI: 10.1038/sj.gene.6364102

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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