Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Interferon-alpha receptor-1 (IFNAR1) variants are associated with protection against cerebral malaria in the Gambia.

Genes and immunity - 1 Jun 2003

Aucan C, Walley A J, Hennig B J W, Fitness J, Frodsham A, Zhang L, Kwiatkowski D, Hill A V S

Abstract excerpt

The chromosome 21q22.11 cytokine receptor cluster contains four genes that encode subunits of the receptors for the cytokines interleukin-10 and interferon-alpha, -beta and -gamma that may have a role in malaria pathogenesis. A total of 15 polymorphic markers located within these genes were initially genotyped in 190 controls and 190 severe malaria cases from The Gambia. Two interferon-alpha receptor-1 (IFNAR1)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chi-Square Distribution
Share to Gambia

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Markers

Share to Immunity, Innate

Share to Malaria, Cerebral

Share to Membrane Proteins

Share to Receptor, Interferon alpha-beta

Share to Receptors, Interferon

Source

Identifiers

PMID: 12761564
DOI: 10.1038/sj.gene.6363962

Genes

IFNAR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Interferon-alpha receptor-1 (IFNAR1) variants are associated with protection against cerebral malaria in the Gambia.PMID 12761564Read ↗

Positive replication and linkage disequilibrium mapping of the chromosome 21q22.1 malaria susceptibility locus.Semantic proximity Read ↗

Type I Interferon Receptor Variants in Gene Regulatory Regions are Associated with Susceptibility to Cerebral Malaria in Malawi.Semantic proximity Read ↗

Interferon-γ (IFNG) microsatellite repeat and single nucleotide polymorphism haplotypes of IFN-α receptor (IFNAR1) associated with enhanced malaria susceptibility in Indian populations.Semantic proximity Read ↗

IFNGR1 gene promoter polymorphisms and susceptibility to cerebral malaria.Semantic proximity Read ↗

A rare non-synonymous c.102C>G SNP in the IFNB1 gene might be a risk factor for cerebral malaria in Indian populations.Semantic proximity Read ↗

Polymorphisms in the Fc gamma receptor IIIA and Toll-like receptor 9 are associated with protection against severe malarial anemia and changes in circulating gamma interferon levels.Semantic proximity Read ↗

Combined promoter haplotypes of the IL10R genes are associated with protection against severe malaria in Gabonese children.Semantic proximity Read ↗

IL1B, IL4R, IL12RB1 and TNF gene polymorphisms are associated with Plasmodium vivax malaria in Brazil.Semantic proximity Read ↗

Reduced interferon (IFN)-α conditioned by IFNA2 (-173) and IFNA8 (-884) haplotypes is associated with enhanced susceptibility to severe malarial anemia and longitudinal all-cause mortality.Semantic proximity Read ↗

scRNA-Seq reveals elevated interferon responses and TNF-α signaling via NFkB in monocytes in children with uncomplicated malariaSemantic proximity Read ↗

Killer-cell immunoglobulin-like receptors and malaria caused by Plasmodium falciparum in The Gambia.Semantic proximity Read ↗

A functional promoter variant in IL12B predisposes to cerebral malaria.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.