Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Multiple yeast genes, including Paf1 complex genes, affect telomere length via telomerase RNA abundance.

Molecular and cellular biology - 1 Jun 2008

Mozdy Amy D, Podell Elaine R, Cech Thomas R

Abstract excerpt

Twofold reductions in telomerase RNA levels cause telomere shortening in both humans and the yeast Saccharomyces cerevisiae. To test whether multiple genes that affect telomere length act by modulating telomerase RNA abundance, we used real-time reverse transcription-PCR to screen S. cerevisiae deletion strains reported to maintain shorter or longer telomeres to determine the levels of their telomerase RNA (TLC1)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Gene Deletion
Share to Gene Expression Regulation, Fungal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Nuclear Proteins

Share to Plasmids

Share to RNA, Fungal

Share to Saccharomyces cerevisiae Proteins

Share to Telomerase

Share to Telomere

Source

Open in PubMed Open full text

Identifiers

PMID: 18411302
DOI: 10.1128/MCB.00512-08
PMCID: PMC2423132

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Multiple yeast genes, including Paf1 complex genes, affect telomere length via telomerase RNA abundance.PMID 18411302Read ↗

Paf1 and Ctr9, core components of the PAF1 complex, maintain low levels of telomeric repeat containing RNA.Semantic proximity Read ↗

Cell cycle-dependent transcription factors control the expression of yeast telomerase RNA.Semantic proximity Read ↗

A genome-wide screen for Saccharomyces cerevisiae deletion mutants that affect telomere length.Semantic proximity Read ↗

Interactions of TLC1 (which encodes the RNA subunit of telomerase), TEL1, and MEC1 in regulating telomere length in the yeast Saccharomyces cerevisiae.Semantic proximity Read ↗

A genome-wide screen for essential yeast genes that affect telomere length maintenance.Semantic proximity Read ↗

Inherited long telomeres induce a genome-wide transcriptional response in budding yeastSemantic proximity Read ↗

Cdc73 suppresses genome instability by mediating telomere homeostasis.Semantic proximity Read ↗

A novel Rap1p-interacting factor, Rif2p, cooperates with Rif1p to regulate telomere length in Saccharomyces cerevisiae.Semantic proximity Read ↗

Phenotypic analysis of Paf1/RNA polymerase II complex mutations reveals connections to cell cycle regulation, protein synthesis, and lipid and nucleic acid metabolism.Semantic proximity Read ↗

The Paf1 complex has functions independent of actively transcribing RNA polymerase II.Semantic proximity Read ↗

Identification of a role for histone H2B ubiquitylation in noncoding RNA 3'-end formation through mutational analysis of Rtf1 in Saccharomyces cerevisiae.Semantic proximity Read ↗

A genetic interaction between RAP1 and telomerase reveals an unanticipated role for RAP1 in telomere maintenanceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.