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Article

A novel Rap1p-interacting factor, Rif2p, cooperates with Rif1p to regulate telomere length in Saccharomyces cerevisiae.

Genes & development - 15 Mar 1997

Wotton D, Shore D

Abstract excerpt

The Saccharomyces cerevisiae Rap1 protein binds with high affinity to sites within the poly(C(1-3)A) tracts at telomeres, where it plays a role in both telomere length regulation and the initiation of telomeric silencing. Rap1p initiates silencing at telomeres by interacting through its carboxy-terminal domain with Sir3p and Sir4p, both of which are required for repression. This same domain of Rap1p also...

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Identifiers

PMID: 9087429
DOI: 10.1101/gad.11.6.748

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A novel Rap1p-interacting factor, Rif2p, cooperates with Rif1p to regulate telomere length in Saccharomyces cerevisiae.PMID 9087429Read ↗

A RAP1-interacting protein involved in transcriptional silencing and telomere length regulation.Semantic proximity Read ↗

A conserved motif within RAP1 has diversified roles in telomere protection and regulation in different organisms.Semantic proximity Read ↗

C-terminal truncation of RAP1 results in the deregulation of telomere size, stability, and function in Saccharomyces cerevisiae.Semantic proximity Read ↗

Regulation of Telomere Length Requires a Conserved N-Terminal Domain of Rif2 in Saccharomyces cerevisiae.Semantic proximity Read ↗

Mutational analysis defines a C-terminal tail domain of RAP1 essential for Telomeric silencing in Saccharomyces cerevisiae.Semantic proximity Read ↗

Structural and functional studies of the Rap1 C-terminus reveal novel separation-of-function mutants.Semantic proximity Read ↗

Yeast Rap1 contributes to genomic integrity by activating DNA damage repair genes.Semantic proximity Read ↗

Telomeric protein distributions and remodeling through the cell cycle in Saccharomyces cerevisiae.Semantic proximity Read ↗

Rap1 affects the length and heterogeneity of human telomeres.Semantic proximity Read ↗

Involvement of the silencer and UAS binding protein RAP1 in regulation of telomere length.Semantic proximity Read ↗

Genetic analysis of Rap1p/Sir3p interactions in telomeric and HML silencing in Saccharomyces cerevisiae.Semantic proximity Read ↗

Rif1 acts through Protein Phosphatase 1 but independent of replication timing to suppress telomere extension in budding yeast.Semantic proximity Read ↗

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