Article
Paf1 and Ctr9, core components of the PAF1 complex, maintain low levels of telomeric repeat containing RNA.
Nucleic acids research - 25 Jan 2018
Rodrigues Joana, Lydall David
Abstract excerpt
The conserved PAF1 complex (Cdc73, Paf1, Ctr9, Leo1 and Rtf1, in yeast), binds RNA pol II, and affects levels of many RNAs. Although PAF1 is a complex, there is evidence that different components perform different functions. In yeast, Cdc73, Paf1 and Ctr9 maintain normal telomerase RNA (TLC1) levels and affect telomere length. Here we report a new connection between the PAF1 complex and telomere biology. We show...
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