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Article

Identification of a role for histone H2B ubiquitylation in noncoding RNA 3'-end formation through mutational analysis of Rtf1 in Saccharomyces cerevisiae.

Genetics - 1 Jun 2011

Tomson Brett N, Davis Christopher P, Warner Marcie H, Arndt Karen M

Abstract excerpt

The conserved eukaryotic Paf1 complex regulates RNA synthesis by RNA polymerase II at multiple levels, including transcript elongation, transcript termination, and chromatin modifications. To better understand the contributions of the Paf1 complex to transcriptional regulation, we generated mutations that alter conserved residues within the Rtf1 subunit of the Saccharomyces cerevisiae Paf1 complex. Importantly,...

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Identifiers

PMID: 21441211
DOI: 10.1534/genetics.111.128645
PMCID: PMC3122317

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