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A genetic interaction between RAP1 and telomerase reveals an unanticipated role for RAP1 in telomere maintenance

1 Sept 2016

Abstract excerpt

RAP1 is one of the components of shelterin, the capping complex at chromosome ends or telomeres, although its role in telomere length maintenance and protection has remained elusive. RAP1 also binds subtelomeric repeats and along chromosome arms, where it regulates gene expression and has been shown to function in metabolism control. Telomerase is the enzyme that elongates telomeres, and its deficiency causes a...

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Share to DNA Repair Mechanisms
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PMID: 27586969
DOI: 10.1111/acel.12517

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