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Article

Cdc73 suppresses genome instability by mediating telomere homeostasis.

PLoS genetics - 1 Jan 2018

Nene Rahul V, Putnam Christopher D, Li Bin-Zhong, Nguyen Katarina G, Srivatsan Anjana, Campbell Christopher S, Desai Arshad, Kolodner Richard D

Abstract excerpt

Defects in the genes encoding the Paf1 complex can cause increased genome instability. Loss of Paf1, Cdc73, and Ctr9, but not Rtf1 or Leo1, caused increased accumulation of gross chromosomal rearrangements (GCRs). Combining the cdc73Δ mutation with individual deletions of 43 other genes, including TEL1 and YKU80, which are involved in telomere maintenance, resulted in synergistic increases in GCR rates. Whole...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 29320491
DOI: 10.1371/journal.pgen.1007170
PMCID: PMC5779705

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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