Article
Phenotypic analysis of Paf1/RNA polymerase II complex mutations reveals connections to cell cycle regulation, protein synthesis, and lipid and nucleic acid metabolism.
Molecular genetics and genomics : MGG - 1 Oct 2002
Betz J L, Chang M, Washburn T M, Porter S E, Mueller C L, Jaehning J A
Abstract excerpt
Paf1 is an RNA polymerase II-associated protein in yeast, which defines a complex that is distinct from the Srb/Mediator holoenzyme. The Paf1 complex, which also contains Ctr9, Cdc73, Hpr1, Ccr4, Rtf1 and Leo1, is required for full expression of a subset of yeast genes, particularly those responsive to signals from the Pkc1/MAP kinase cascade. We have extensively characterized the pleiotropic phenotypes of...
Topics
- Cell Cycle
- Fungal Proteins
- Gene Expression Regulation, Fungal
- Lipid Metabolism
- Multienzyme Complexes
- Mutation
- Nuclear Proteins
- Nucleic Acids
- Phenotype
- RNA Polymerase II
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins