Article
The Paf1 complex has functions independent of actively transcribing RNA polymerase II.
Molecular cell - 21 May 2004
Mueller Cherie L, Porter Stephanie E, Hoffman Matthew G, Jaehning Judith A
Abstract excerpt
The yeast Paf1 complex, minimally composed of Paf1, Ctr9, Cdc73, Rtf1, and Leo1, was originally isolated in association with RNA polymerase II (Pol II). Paf1 complex components are abundant and colocalize with Pol II on chromatin at promoters and in the coding regions of actively transcribed genes. Loss of Paf1 results in severe phenotypes and reduced amounts of other Paf1 factors, with little effect on abundance...
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