Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Interactions of TLC1 (which encodes the RNA subunit of telomerase), TEL1, and MEC1 in regulating telomere length in the yeast Saccharomyces cerevisiae.

Molecular and cellular biology - 1 Sept 1999

Ritchie K B, Mallory J C, Petes T D

Abstract excerpt

In the yeast Saccharomyces cerevisiae, chromosomes terminate with a repetitive sequence [poly(TG(1-3))] 350 to 500 bp in length. Strains with a mutation of TEL1, a homolog of the human gene (ATM) mutated in patients with ataxia telangiectasia, have short but stable telomeric repeats. Mutations of TLC1 (encoding the RNA subunit of telomerase) result in strains that have continually shortening telomeres and a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Ataxia Telangiectasia Mutated Proteins
Share to Nucleic Acid Conformation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to RNA, Fungal

Share to RNA, Long Noncoding

Share to RNA, Untranslated

Share to Telomerase

Share to Telomere

Source

Open in PubMed Open full text

Identifiers

PMID: 10454554
DOI: 10.1128/MCB.19.9.6065
PMCID: PMC84515

Genes

ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Interactions of TLC1 (which encodes the RNA subunit of telomerase), TEL1, and MEC1 in regulating telomere length in the yeast Saccharomyces cerevisiae.PMID 10454554Read ↗

Regulation of genome stability by TEL1 and MEC1, yeast homologs of the mammalian ATM and ATR genes.Semantic proximity Read ↗

RAD50 and RAD51 define two pathways that collaborate to maintain telomeres in the absence of telomerase.Semantic proximity Read ↗

Multiple yeast genes, including Paf1 complex genes, affect telomere length via telomerase RNA abundance.Semantic proximity Read ↗

Mec1ATR is needed for extensive telomere elongation in response to ethanol in yeast.Semantic proximity Read ↗

Senescence mutants of Saccharomyces cerevisiae with a defect in telomere replication identify three additional EST genes.Semantic proximity Read ↗

A genetic interaction between RAP1 and telomerase reveals an unanticipated role for RAP1 in telomere maintenanceSemantic proximity Read ↗

Telomerase, the recombination machinery and Rap1 play redundant roles in yeast telomere protection.Semantic proximity Read ↗

Varying the number of telomere-bound proteins does not alter telomere length in tel1Delta cells.Semantic proximity Read ↗

C-terminal truncation of RAP1 results in the deregulation of telomere size, stability, and function in Saccharomyces cerevisiae.Semantic proximity Read ↗

Telomerase-independent proliferation is influenced by cell type in Saccharomyces cerevisiae.Semantic proximity Read ↗

Two survivor pathways that allow growth in the absence of telomerase are generated by distinct telomere recombination events.Semantic proximity Read ↗

TEL1, a gene involved in controlling telomere length in S. cerevisiae, is homologous to the human ataxia telangiectasia gene.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.