Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

<i>DUSP1</i> Is Controlled by p53 during the Cellular Response to Oxidative Stress

1 Apr 2008

Abstract excerpt

p53 controls the cellular response to genotoxic stress through multiple mechanisms. We report here that p53 regulates DUSP1, a dual-specific threonine and tyrosine phosphatase with stringent substrate specificity for mitogen-activated protein kinase (MAPK). DUSP1 is a potent inhibitor of MAPK activity through dephosphorylation of MAPK. In a colon cancer cell line containing inducible ectopic p53, DUSP1 protein...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Protein Tyrosine Phosphatases
Share to RNA modifications and cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 18403641
DOI: 10.1158/1541-7786.mcr-07-2019

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

<i>DUSP1</i> Is Controlled by p53 during the Cellular Response to Oxidative StressPMID 18403641Read ↗

Disruption of a regulatory loop between DUSP1 and p53 contributes to hepatocellular carcinoma development and progression.Semantic proximity Read ↗

DSCP1, a novel TP53-inducible gene, is upregulated by strong genotoxic stresses and its overexpression inhibits tumor cell growth in vitro.Semantic proximity Read ↗

Identification and characterization of a p53 homologue in <i>Drosophila melanogaster</i>Semantic proximity Read ↗

Identification and functional characterization of the human glutathione S-transferase P1 gene as a novel transcriptional target of the p53 tumor suppressor gene.Semantic proximity Read ↗

DRAGO (KIAA0247), a new DNA damage-responsive, p53-inducible gene that cooperates with p53 as oncosuppressor. [Corrected].Semantic proximity Read ↗

dapk1, encoding an activator of a p19ARF-p53-mediated apoptotic checkpoint, is a transcription target of p53.Semantic proximity Read ↗

A genome-scale protein interaction profile of <i>Drosophila</i> p53 uncovers additional nodes of the human p53 networkSemantic proximity Read ↗

DUSP 4 expression identifies a subset of colorectal cancer tumors that differ in MAPK activation, regardless of the genotype.Semantic proximity Read ↗

p53 Requires the Stress Sensor USF1 to Direct Appropriate Cell Fate DecisionSemantic proximity Read ↗

Negative feedback regulation of MAPK signaling is an important driver of CLL progressionSemantic proximity Read ↗

Transcriptional Regulation and Biological Functions of Selenium-Binding Protein 1 in Colorectal Cancer In Vitro and in Nude Mouse XenograftsSemantic proximity Read ↗

The p53 tumor suppressor protein activates transcription of DUSP13 isoform from the alternative promoter in intronSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.