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Article

p53 Requires the Stress Sensor USF1 to Direct Appropriate Cell Fate Decision

15 May 2014

Abstract excerpt

Genomic instability is a major hallmark of cancer. To maintain genomic integrity, cells are equipped with dedicated sensors to monitor DNA repair or to force damaged cells into death programs. The tumor suppressor p53 is central in this process. Here, we report that the ubiquitous transcription factor Upstream Stimulatory factor 1 (USF1) coordinates p53 function in making proper cell fate decisions. USF1...

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PMID: 24831529
DOI: 10.1371/journal.pgen.1004309

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