Article

Negative feedback regulation of MAPK signaling is an important driver of CLL progression

2023-01-19

Abstract excerpt

<title>Abstract</title> <p>Despite several potent targeted treatments for chronic lymphocytic leukemia (CLL), the clinical challenge of treating drug-resistant disease is emerging. In this study, we discovered that the dual-specific phosphatases DUSP1 and DUSP6 are required to negatively regulate Mitogen-activated protein kinases (MAPK) and thus counterbalance excessive MAPK activity to prevent apoptosis in CLL....

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Literature Corpus work: 369b5b07-6a33-5523-9233-1a072b469752
DOI: 10.21203/rs.3.rs-2481423/v1

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