Article
DUSP 4 expression identifies a subset of colorectal cancer tumors that differ in MAPK activation, regardless of the genotype.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals - 1 Sept 2013
De Vriendt Veerle, De Roock Wendy, Di Narzo Antonio Fabio, Tian Sun, Biesmans Bart, Jacobs Bart, Budinska Eva, Sagaert Xavier, Rossi Simona, D'Ario Giovanni, Delorenzi Mauro, Simon Iris, Vecchione Loredana, Tejpar Sabine
Abstract excerpt
As dual-specificity phosphatase (DUSP) expression has been correlated to sensitivity to MEK inhibitors, DUSP expression levels may indicate activation of the mitogen-activated protein kinase (MAPK) pathway in many tumor types. In this study, we investigate if DUSP levels can indicate different levels of MAPK activation within colorectal cancer (CRC) patients. In three different CRC patient microarray datasets, we...
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