Article
DRAGO (KIAA0247), a new DNA damage-responsive, p53-inducible gene that cooperates with p53 as oncosuppressor. [Corrected].
Journal of the National Cancer Institute - 1 Apr 2014
Polato Federica, Rusconi Paolo, Zangrossi Stefano, Morelli Federica, Boeri Mattia, Musi Alberto, Marchini Sergio, Castiglioni Vittoria, Scanziani Eugenio, Torri Valter, Broggini Massimo
Abstract excerpt
BACKGROUND: p53 influences genomic stability, apoptosis, autophagy, response to stress, and DNA damage. New p53-target genes could elucidate mechanisms through which p53 controls cell integrity and response to damage. METHODS: DRAGO (drug-activated gene overexpressed, KIAA0247) was characterized by bioinformatics methods as well as by real-time polymerase chain reaction, chromatin immunoprecipitation and...
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