Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification and characterization of a p53 homologue in <i>Drosophila melanogaster</i>

20 Jun 2000

Abstract excerpt

The tumor suppressor gene p53 in mammalian cells plays a critical role in safeguarding the integrity of genome. It functions as a sequence-specific transcription factor. Upon activation by a variety of cellular stresses, p53 transactivates downstream target genes, through which it regulates cell cycle and apoptosis. However, little is known about p53 in invertebrates. Here we report the identification and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Cancer Research and Treatments
Share to Ubiquitin and proteasome pathways

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 10860994
DOI: 10.1073/pnas.97.13.7301

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification and characterization of a p53 homologue in <i>Drosophila melanogaster</i>PMID 10860994Read ↗

A genome-scale protein interaction profile of <i>Drosophila</i> p53 uncovers additional nodes of the human p53 networkSemantic proximity Read ↗

In vivo p53 function is indispensable for DNA damage-induced apoptotic signaling in Drosophila.Semantic proximity Read ↗

The functional domains in p53 family proteins exhibit both common and distinct properties.Semantic proximity Read ↗

TATA binding protein associated factor 3 (TAF3) interacts with p53 and inhibits its functionSemantic proximity Read ↗

Structural Differences in the DNA Binding Domains of Human p53 and Its C. elegans Ortholog Cep-1Semantic proximity Read ↗

Tracing the protectors path from the germ line to the genome.Semantic proximity Read ↗

<i>Drosophila p53</i> isoforms have overlapping and distinct functions in germline genome integrity and oocyte quality controlSemantic proximity Read ↗

New Δ246p53 isoform responds to DNA damage to enhance p53 family functions in cellular senescenceSemantic proximity Read ↗

Evaluating Drosophila p53 as a model system for studying cancer mutations.Semantic proximity Read ↗

Drosophila p53 directs nonapoptotic programs in postmitotic tissueSemantic proximity Read ↗

<i>DUSP1</i> Is Controlled by p53 during the Cellular Response to Oxidative StressSemantic proximity Read ↗

Drosophila p53 preserves genomic stability by regulating cell death.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.