Article
DSCP1, a novel TP53-inducible gene, is upregulated by strong genotoxic stresses and its overexpression inhibits tumor cell growth in vitro.
International journal of oncology - 1 Mar 2004
Hata Tatsuo, Ogawa Takenori, Yokoyama Tada-aki, Fukushige Shinichi, Horii Akira, Furukawa Toru
Abstract excerpt
TP53-inducible genes play crucial roles from many biological aspects including cell cycle control, DNA repair, and apoptosis. Herein we report the identification and characterization of a novel TP53-inducible gene, DSCP1 (damage stimulated cytoplasmic protein 1), localized at 17q11. The gene was expressed ubiquitously in normal adult tissues; its protein product was localized mainly in the cytoplasm with...
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