Article

The p53 tumor suppressor protein activates transcription of DUSP13 isoform from the alternative promoter in intron

2024-02-26

Abstract excerpt

The p53 tumor suppressor protein is an activator of transcription. Diverse stress factors lead to various sets of posttranslational modifications of p53 what results in different sets of upregulat-ed genes. We noticed that actinomycin D and nutlin-3a (A+N) synergize in inducing activating phosphorylations of p53 and upregulation of selected p53-target genes. Here we found that one of these genes is DUSP13, which c...

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Literature Corpus work: 7d742504-804b-55d7-8628-564cefe4c592
DOI: 10.20944/preprints202309.1653.v2

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