Article
Identification and functional characterization of the human glutathione S-transferase P1 gene as a novel transcriptional target of the p53 tumor suppressor gene.
Molecular cancer research : MCR - 1 May 2008
Lo Hui-Wen, Stephenson Lisa, Cao Xinyu, Milas Mira, Pollock Raphael, Ali-Osman Francis
Abstract excerpt
The glutathione S-transferase P1 (GSTP1) is involved in multiple cellular functions, including phase II metabolism, stress response, signaling, and apoptosis. The mechanisms underlying the significantly high GSTP1 expression in many human tumors are, however, currently not well understood. We report here that the GSTP1 gene is a heretofore unrecognized downstream transcriptional target of the tumor suppressor...
Topics
- Amino Acid Motifs
- Base Sequence
- Binding Sites
- Brain Neoplasms
- Cell Line, Tumor
- Cisplatin
- Drug Resistance, Neoplasm
- Gene Expression Regulation, Neoplastic
- Genes, Tumor Suppressor
- Genes, p53
- Glutathione S-Transferase pi
- Humans
- Molecular Sequence Data