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Article

A genome-scale protein interaction profile of <i>Drosophila</i> p53 uncovers additional nodes of the human p53 network

22 Mar 2010

Abstract excerpt

The genome of the fruitfly Drosophila melanogaster contains a single p53-like protein, phylogenetically related to the ancestor of the mammalian p53 family of tumor suppressors. We reasoned that a comprehensive map of the protein interaction profile of Drosophila p53 (Dmp53) might help identify conserved interactions of the entire p53 family in man. Using a genome-scale in vitro expression cloning approach, we...

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PMID: 20308539
DOI: 10.1073/pnas.1002447107

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