Article
Resistance of IAPs to methylation reprogramming may provide a mechanism for epigenetic inheritance in the mouse.
Genesis (New York, N.Y. : 2000) - 1 Feb 2003
Lane Natasha, Dean Wendy, Erhardt Sylvia, Hajkova Petra, Surani Azim, Walter Jörn, Reik Wolf
Abstract excerpt
Genome-wide epigenetic reprogramming by demethylation occurs in early mouse embryos and primordial germ cells. In early embryos many single-copy sequences become demethylated both by active and passive demethylation, whereas imprinted gene methylation remains unaffected. In primordial germ cells single-copy and imprinted sequences are demethylated, presumably by active demethylation. Here we investigated...
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