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Article

The endonuclease activity of Mili fuels piRNA amplification that silences LINE1 elements.

Nature - 23 Oct 2011

De Fazio Serena, Bartonicek Nenad, Di Giacomo Monica, Abreu-Goodger Cei, Sankar Aditya, Funaya Charlotta, Antony Claude, Moreira Pedro N, Enright Anton J, O'Carroll Dónal

Abstract excerpt

Piwi proteins and Piwi-interacting RNAs (piRNAs) have conserved functions in transposon silencing. The murine Piwi proteins Mili and Miwi2 (also called Piwil2 and Piwil4, respectively) direct epigenetic LINE1 and intracisternal A particle transposon silencing during genome reprogramming in the em...

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Identifiers

PMID: 22020280
DOI: 10.1038/nature10547

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22020280-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

The endonuclease activity of Mili fuels piRNA amplification that silences LINE1 elements.PMID 22020280Read ↗

Developmentally regulated piRNA clusters implicate MILI in transposon control.Semantic proximity Read ↗

Miwi catalysis is required for piRNA amplification-independent LINE1 transposon silencing.Semantic proximity Read ↗

<i>yama</i> , a mutant allele of <i>Mov10l1</i> , disrupts retrotransposon silencing and piRNA biogenesisSemantic proximity Read ↗

yama, a mutant allele of Mov10l1, disrupts retrotransposon silencing and piRNA biogenesis.Semantic proximity Read ↗

Restricted and non-essential redundancy of RNAi and piRNA pathways in mouse oocytesSemantic proximity Read ↗

Intact piRNA pathway prevents L1 mobilization in male meiosis.Semantic proximity Read ↗

DNA methylation of retrotransposon genes is regulated by Piwi family members MILI and MIWI2 in murine fetal testes.Semantic proximity Read ↗

PNLDC1 catalysis and postnatal germline function are required for piRNA trimming, LINE1 silencing, and spermatogenesis in miceSemantic proximity Read ↗

RNF17 blocks promiscuous activity of PIWI proteins in mouse testes.Semantic proximity Read ↗

An ancient transcription factor initiates the burst of piRNA production during early meiosis in mouse testes.Semantic proximity Read ↗

Restricted and non-essential redundancy of RNAi and piRNA pathways in mouse oocytes.Semantic proximity Read ↗

Mouse MOV10L1 associates with Piwi proteins and is an essential component of the Piwi-interacting RNA (piRNA) pathway.Semantic proximity Read ↗

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