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Article

Developmentally regulated piRNA clusters implicate MILI in transposon control.

Science (New York, N.Y.) - 4 May 2007

Aravin Alexei A, Sachidanandam Ravi, Girard Angelique, Fejes-Toth Katalin, Hannon Gregory J

Abstract excerpt

Nearly half of the mammalian genome is composed of repeated sequences. In Drosophila, Piwi proteins exert control over transposons. However, mammalian Piwi proteins, MIWI and MILI, partner with Piwi-interacting RNAs (piRNAs) that are depleted of repeat sequences, which raises questions about a ro...

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Identifiers

PMID: 17446352
DOI: 10.1126/science.1142612

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17446352-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Developmentally regulated piRNA clusters implicate MILI in transposon control.PMID 17446352Read ↗

The endonuclease activity of Mili fuels piRNA amplification that silences LINE1 elements.Semantic proximity Read ↗

Mouse MOV10L1 associates with Piwi proteins and is an essential component of the Piwi-interacting RNA (piRNA) pathway.Semantic proximity Read ↗

Miwi catalysis is required for piRNA amplification-independent LINE1 transposon silencing.Semantic proximity Read ↗

piRNA-mediated gene regulation and adaptation to sex-specific transposon expression in <i>D. melanogaster</i> male germlineSemantic proximity Read ↗

Biology of PIWI-interacting RNAs: new insights into biogenesis and function inside and outside of germlines.Semantic proximity Read ↗

Zili is required for germ cell differentiation and meiosis in zebrafish.Semantic proximity Read ↗

Mice deficient for a small cluster of Piwi-interacting RNAs implicate Piwi-interacting RNAs in transposon control.Semantic proximity Read ↗

An ancient transcription factor initiates the burst of piRNA production during early meiosis in mouse testes.Semantic proximity Read ↗

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Antagonistic roles of Nibbler and Hen1 in modulating piRNA 3' ends in Drosophila.Semantic proximity Read ↗

DNA methylation of retrotransposon genes is regulated by Piwi family members MILI and MIWI2 in murine fetal testes.Semantic proximity Read ↗

Minotaur is critical for primary piRNA biogenesis.Semantic proximity Read ↗

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