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Article

An ancient transcription factor initiates the burst of piRNA production during early meiosis in mouse testes.

Molecular cell - 11 Apr 2013

Li Xin Zhiguo, Roy Christian K, Dong Xianjun, Bolcun-Filas Ewelina, Wang Jie, Han Bo W, Xu Jia, Moore Melissa J, Schimenti John C, Weng Zhiping, Zamore Phillip D

Abstract excerpt

Animal germ cells produce PIWI-interacting RNAs (piRNAs), small silencing RNAs that suppress transposons and enable gamete maturation. Mammalian transposon-silencing piRNAs accumulate early in spermatogenesis, whereas pachytene piRNAs are produced later during postnatal spermatogenesis and account for >95% of all piRNAs in the adult mouse testis. Mutants defective for pachytene piRNA pathway proteins fail to...

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Identifiers

PMID: 23523368
DOI: 10.1016/j.molcel.2013.02.016
PMCID: PMC3671569

Genes

MYB

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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An ancient transcription factor initiates the burst of piRNA production during early meiosis in mouse testes.PMID 23523368Read ↗

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