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Article

Miwi catalysis is required for piRNA amplification-independent LINE1 transposon silencing.

Nature - 27 Nov 2011

Reuter Michael, Berninger Philipp, Chuma Shinichiro, Shah Hardik, Hosokawa Mihoko, Funaya Charlotta, Antony Claude, Sachidanandam Ravi, Pillai Ramesh S

Abstract excerpt

Repetitive-element-derived Piwi-interacting RNAs (piRNAs) act together with Piwi proteins Mili (also known as Piwil2) and Miwi2 (also known as Piwil4) in a genome defence mechanism that initiates transposon silencing via DNA methylation in the mouse male embryonic germ line. This silencing depends on the participation of the Piwi proteins in a slicer-dependent piRNA amplification pathway and is essential for male...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22121019
DOI: 10.1038/nature10672

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Miwi catalysis is required for piRNA amplification-independent LINE1 transposon silencing.PMID 22121019Read ↗

The endonuclease activity of Mili fuels piRNA amplification that silences LINE1 elements.Semantic proximity Read ↗

Mouse MOV10L1 associates with Piwi proteins and is an essential component of the Piwi-interacting RNA (piRNA) pathway.Semantic proximity Read ↗

Mice deficient for a small cluster of Piwi-interacting RNAs implicate Piwi-interacting RNAs in transposon control.Semantic proximity Read ↗

Developmentally regulated piRNA clusters implicate MILI in transposon control.Semantic proximity Read ↗

Zili is required for germ cell differentiation and meiosis in zebrafish.Semantic proximity Read ↗

Biology of PIWI-interacting RNAs: new insights into biogenesis and function inside and outside of germlines.Semantic proximity Read ↗

piRNAs and their involvement in male germline development in mice.Semantic proximity Read ↗

Function of Piwi, a nuclear Piwi/Argonaute protein, is independent of its slicer activity.Semantic proximity Read ↗

PNLDC1, mouse pre-piRNA Trimmer, is required for meiotic and post-meiotic male germ cell development.Semantic proximity Read ↗

piRNA pathway targets active LINE1 elements to establish the repressive H3K9me3 mark in germ cells.Semantic proximity Read ↗

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A piRNA-lncRNA regulatory network initiates responder and trailer piRNA formation during mosquito embryonic developmentSemantic proximity Read ↗

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