Article
Transmission of HIV-1 CTL escape variants provides HLA-mismatched recipients with a survival advantage.
PLoS pathogens - 21 Mar 2008
Chopera Denis R, Woodman Zenda, Mlisana Koleka, Mlotshwa Mandla, Martin Darren P, Seoighe Cathal, Treurnicht Florette, de Rosa Debra Assis, Hide Winston, Karim Salim Abdool, Gray Clive M, Williamson Carolyn
Abstract excerpt
One of the most important genetic factors known to affect the rate of disease progression in HIV-infected individuals is the genotype at the Class I Human Leukocyte Antigen (HLA) locus, which determines the HIV peptides targeted by cytotoxic T-lymphocytes (CTLs). Individuals with HLA-B*57 or B*5801 alleles, for example, target functionally important parts of the Gag protein. Mutants that escape these CTL...
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